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T2* reduction in patients with acute post-traumatic headache.

Simona Nikolova1, Todd J Schwedt1,2, Jing Li3

  • 1Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.

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|October 13, 2021
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Summary

Acute post-traumatic headache is linked to iron buildup in the brain. This iron accumulation may indicate mild traumatic brain injury and influence headache frequency.

Keywords:
T2*anatomicalconcussionimagingironmagnetic resonance imagingmigrainemild traumatic brain injurystructural

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Iron accumulation in pain-processing brain regions is linked to migraines.
  • Brain structural changes in post-traumatic headache (PTH) are not well understood.

Purpose of the Study:

  • To investigate iron accumulation in individuals with acute PTH attributed to mild traumatic brain injury (mTBI).
  • To determine if magnetic resonance transverse relaxation rates (T2*) correlate with acute PTH.

Main Methods:

  • Compared quantitative T2* maps from 3T brain MRI in 20 individuals with acute PTH and 20 healthy controls.
  • Used age-matched paired t-tests to compare T2* values.
  • Employed multiple linear regression to assess associations between T2* values, headache frequency, and mTBI history.

Main Results:

  • Individuals with acute PTH exhibited lower T2* values than controls in numerous cortical, subcortical, and brainstem regions.
  • Lower T2* in specific regions correlated negatively with mTBI history.
  • Lower T2* in other brain areas correlated negatively with headache frequency.

Conclusions:

  • Acute PTH is associated with iron accumulation in multiple brain regions.
  • Iron accumulation may be integral to the pathophysiology or serve as a marker for mTBI and PTH.