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Updated: Jun 15, 2026

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
Published on: January 27, 2023
Drugs and liver injury: a not to be overlooked binomial in COVID-19
M Vitrone1, F Mele1, E Durante-Mangoni2,3
1Department of Advanced Medical & Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy.
Abstract:
SARS-CoV-2 infection (COVID-19) results predominantly in pulmonary involvement but a direct, virus-induced liver damage may also occur, whose mechanisms are being actively investigated. Accordingly, it appears of utmost importance to monitor liver function and carefully evaluate hepatic safety of the various drugs administered during COVID-19. In this respect, many drugs, biological agents and novel molecules, whose efficacy in COVID-19 is under scrutiny, have also been shown to potentially cause or worsen liver damage. In this article, we review safety data of established as well as promising agents for COVID-19.
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