Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impaired monocyte function in glycogen storage disease type Ib.

N Ueno, M Tomita, T Ariga

    European Journal of Pediatrics
    |September 1, 1986
    PubMed
    Summary

    Glycogen storage disease type Ib impairs phagocyte function. Neutrophils and monocytes show defects in respiratory burst, with neutrophils also lacking motility, impacting immune response.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

    Physical review letters·2021
    Same author

    Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

    Living reviews in relativity·2020
    Same author

    Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

    Living reviews in relativity·2018
    Same author

    Recovery of cortical blood flow and dementia after superficial temporal-middle cerebral artery bypass in a patient with severe carotid occlusive lesions: A two-year follow-up study.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Radiofrequency capacitive hyperthermia combined with irradiation or chemotherapy for patients with invasive bladder-cancer.

    Oncology reports·2011
    Same author

    Radiation pneumonitis in patients with lung and mediastinal tumours: a retrospective study of risk factors focused on pulmonary emphysema.

    The British journal of radiology·2011

    Area of Science:

    • Immunology
    • Metabolic Disorders
    • Cellular Biology

    Background:

    • Glycogen storage disease type Ib is a rare genetic disorder affecting glucose metabolism.
    • Phagocytes, including neutrophils and monocytes, are crucial immune cells involved in pathogen clearance.

    Observation:

    • This study investigated phagocyte function in a patient with glycogen storage disease type Ib.
    • Specific functional assays were performed on neutrophils and monocytes isolated from the patient.

    Findings:

    • Neutrophils exhibited defects in both motility and respiratory burst.
    • Monocytes displayed a defect in respiratory burst but retained normal motility.
    • These findings indicate differential impacts of the disease on phagocyte subtypes.

    Related Experiment Videos

    Implications:

    • The glucose-6-phosphate transport system is vital for neutrophil and monocyte function.
    • Energy metabolism for motility differs between neutrophils and monocytes in this condition.
    • Understanding these cellular defects can inform therapeutic strategies for glycogen storage disease type Ib.