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Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients

Ricardo Neto1,2,3, Luciano Pereira1,2,3, Juliana Magalhães1

  • 1Institute for Innovation and Health Research (I3S), Institute of Biomedical Engineering (INEB), Nephrology and Infectious Diseases Research Group, University of Porto, Porto, Portugal.

Plos One
|October 13, 2021
PubMed

Insights

Vascular calcification is common in chronic kidney disease (CKD) patients before dialysis. Low bone formation rate is linked to vascular calcification, suggesting it

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Bone Biology

Background:

  • Vascular calcification (VC) is prevalent in chronic kidney disease (CKD), predicting cardiovascular events.
  • VC is associated with mineral metabolism disorders and bone changes in CKD.
  • Limited data exists on VC in predialysis CKD patients.

Purpose of the Study:

  • To investigate the prevalence and risk factors of vascular calcification in predialysis CKD patients.
  • To examine the relationship between vascular calcification and bone histomorphometry in this population.

Main Methods:

  • Cross-sectional study of 56 predialysis CKD patients.
  • Transiliac bone biopsy with histomorphometric evaluation.
  • Vascular calcification assessed using Kauppila and Adragão scores.

Main Results:

  • Vascular calcification detected in two-thirds of patients.
  • VC patients were more likely male, diabetic, with higher sclerostin and osteoprotegerin levels.
  • Lower bone formation rate observed in patients with VC, independently associated with VC presence.

Conclusions:

  • Vascular calcification is highly prevalent in predialysis CKD, particularly in diabetics.
  • An independent association exists between low bone formation rate and VC.
  • Low bone turnover may be a non-traditional cardiovascular risk factor in predialysis CKD.
Abstract

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