Related Experiment Video
Updated: Oct 17, 2025
Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
Published on: November 6, 2019
Malassezia dermatitis in the dog: a retrospective histopathological and immunopathological study of 86 cases
Elizabeth A Mauldin1, Danny W Scott1,2, William H Miller1,2
1Departments of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Abstract:
A retrospective histopathological and immunopathological study was conducted on 86 dogs with Malassezia dermatitis. West Highland White terriers, English Setters, Shih Tzus, Basset Hounds, American Cocker Spaniels, spayed females, and castrated males were found to be at increased risk. The histopathological reaction pattern of lymphocytic superficial perivascular to interstitial dermatitis with parakeratotic hyperkeratosis, irregular epidermal hyperplasia, diffuse intercellular oedema and lymphocytic exocytosis was found to be consistent with a diagnosis of Malassezia dermatitis whether yeast were histologically visible (73.3% of the cases) or not (26.7%). Immunopathological studies revealed that 60- > 90% of the inflammatory cells within the epidermis, and 25-75% of those within the dermis were CD3+T lymphocytes, and that the only immunoglobulin-positive cells were dermal plasma cells.
