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Related Concept Videos

Epistasis01:39

Epistasis

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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Pleiotropy01:33

Pleiotropy

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Lupoid Dermatosis in Five German Short-haired Pointers.

Margreet W Vroom1, MANDy J Theaker2, Joan R Rest3

  • 1*Veterinaire Specialisten Oisterwijk, Boxtelsebaan 6, 5061 VD, Oisterwijk, The Netherlands.

Veterinary Dermatology
|October 14, 2021
PubMed
Summary
This summary is machine-generated.

Lupoid dermatosis is a rare genetic skin disease in young German short-haired pointers. Diagnosis involves clinical and histopathological exams, with a guarded prognosis. Fatty acid and symptomatic treatments may help manage this condition.

Keywords:
Dry seborrhoeaExfoliating skin disorderGerman short-haired pointerHereditary lupoid dermatosisInterface dermatitis

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Area of Science:

  • Veterinary Dermatology
  • Canine Genetics
  • Dermatopathology

Background:

  • Lupoid dermatosis is a rare skin condition observed in German short-haired pointers.
  • While few cases are reported, it is suspected to be a genodermatosis.

Observation:

  • The disease primarily affects young dogs.
  • No specific sex predisposition has been identified.
  • Clinical signs and histopathological examination of skin biopsies are crucial for diagnosis.

Findings:

  • The condition has been consistently described in German short-haired pointers.
  • Diagnosis relies on a combination of clinical presentation and histopathological findings.
  • The prognosis for lupoid dermatosis is generally poor.

Implications:

  • Early diagnosis and intervention are important for managing canine skin diseases.
  • Further research into the genetic basis of lupoid dermatosis could improve understanding and treatment.
  • Fatty acid supplementation and symptomatic treatments offer potential therapeutic avenues for affected dogs.