Related Experiment Video

Updated: Oct 17, 2025

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
09:26

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Published on: January 22, 2021

7.2K

Post-antibiotic effect of cephalexin against isolates of Staphylococcus intermedius obtained from cases of canine

E Bousquet1, J-P Ganiere2, N Ruvoen2

  • 1Virbac, BP 27, 06511 Carros Cedex, France.

Veterinary Dermatology
|October 14, 2021
PubMed

Insights

The post-antibiotic effect (PAE) of cephalexin against Staphylococcus intermedius in dogs was studied. Longer exposure and higher concentrations of cephalexin resulted in a longer PAE, suggesting clinical relevance for treating canine pyoderma.

Area of Science:

  • Veterinary Microbiology
  • Pharmacology
  • Dermatology

Background:

  • Canine pyoderma is a common skin infection in dogs.
  • Staphylococcus intermedius is a primary bacterial pathogen involved in canine pyoderma.
  • Understanding the post-antibiotic effect (PAE) is crucial for optimizing antibiotic therapy.

Purpose of the Study:

  • To determine the in vitro post-antibiotic effect (PAE) of cephalexin against Staphylococcus intermedius isolates from dogs.
  • To investigate the influence of exposure duration and concentration on cephalexin's PAE.
  • To assess the potential clinical relevance of cephalexin's PAE in treating canine pyoderma.

Main Methods:

  • Broth dilution method was used to determine the PAE.
  • Five isolates of Staphylococcus intermedius from canine pyoderma cases were tested.
  • Two exposure durations and three concentrations of cephalexin were evaluated.

Main Results:

  • The PAE of cephalexin against Staphylococcus intermedius was observed.
  • Increasing exposure time and concentration of cephalexin led to a longer PAE.
  • The mean PAE ranged from 0.7 to 3.3 hours.

Conclusions:

  • Cephalexin exhibits a significant post-antibiotic effect against Staphylococcus intermedius in vitro.
  • The findings suggest that cephalexin's PAE may be clinically relevant for designing effective treatment regimens for canine pyoderma.
  • Optimizing cephalexin dosage based on PAE could improve therapeutic outcomes in dogs.
Keywords:
Staphylococcus intermediuscephalexindogpost-antibiotic effectpyoderma

More Related Videos

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds06:36

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

Published on: September 8, 2021

2.9K
Multi-scale Analysis of Bacterial Growth Under Stress Treatments12:08

Multi-scale Analysis of Bacterial Growth Under Stress Treatments

Published on: November 28, 2019

9.6K

Related Concept Videos

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
5.1K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
73
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
451
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
26