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Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

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Paraneoplastic pemphigus in a dog.

Lemmens¹, De Bruin², De Meulemeester¹

¹Dierenkliniek Plantijn, Antwerpen, Belgium.

Veterinary Dermatology

|October 14, 2021

Summary

This summary is machine-generated.

This case study details paraneoplastic pemphigus in a young Bouvier, characterized by severe oral and skin lesions. The condition was linked to thymic lymphoma, leading to euthanasia despite treatment attempts.

Keywords:

Western blot anti desmoplakin autoantibody canine direct immunofluorescence lymphoma paraneoplastic pemphigus

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Area of Science:

Veterinary Dermatology
Immunopathology
Oncology

Background:

Paraneoplastic pemphigus is a rare autoimmune blistering disease.
It is associated with an underlying neoplasm, often lymphoma.
Oral and mucocutaneous lesions are characteristic.

Purpose of the Study:

To report a case of paraneoplastic pemphigus in a canine patient.
To describe the clinical, histopathological, and immunopathological findings.
To highlight the association with thymic lymphoma.

Main Methods:

Clinical examination and lesion description.
Histopathological examination of skin and oral biopsies.
Immunofluorescence and Western blot analysis of patient serum.

Main Results:

A 7-year-old Bouvier presented with severe oral ulcerations and subsequent mucocutaneous blistering.
Histopathology showed features of erythema multiforme initially, later evolving to pemphigus vulgaris.
Post-mortem revealed thymic lymphoma; serum analysis detected autoantibodies against 210 and 190 kDa proteins.

Conclusions:

This case confirms paraneoplastic pemphigus in a dog associated with thymic lymphoma.
Diagnostic challenges include initial misdiagnosis and the need for advanced serological testing.
Early recognition and understanding of paraneoplastic syndromes are crucial in veterinary medicine.