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Updated: Oct 17, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Infliximab-induced interstitial lung disease
Theodoros Karampitsakos1, Ourania Papaioannou1, Fotios Sampsonas2
1Department of Respiratory Medicine, University Hospital of Patras, Patras, Greece.
A 70-year-old man developed drug-induced interstitial lung disease (DI-ILD) from infliximab treatment for psoriasis. Discontinuing the medication led to significant recovery, highlighting the importance of medication review in respiratory cases.
Area of Science:
- Pulmonology
- Rheumatology
- Pharmacology
Background:
- Interstitial lung disease (ILD) can be a rare but serious side effect of biologic therapies.
- Infliximab, a TNF-alpha inhibitor, is used for various autoimmune conditions including psoriasis.
Observation:
- A 70-year-old male presented with a 6-month history of non-productive cough.
- High-resolution CT showed a reticular pattern, nodules, and ground-glass opacities.
- Pulmonary function tests revealed impaired function and reduced diffusing capacity.
Findings:
- Bronchoalveolar lavage showed lymphocytosis.
- The patient had a history of long-term infliximab use for psoriasis.
- A diagnosis of drug-induced interstitial lung disease was established.
Implications:
- Discontinuation of infliximab resulted in significant radiological and functional improvement.
- Corticosteroids were not required for recovery.
- This case underscores the importance of considering drug-induced lung injury in patients on biologic agents.
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