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Related Experiment Video

Updated: Oct 17, 2025

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

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Published on: October 2, 2015

Radiation-associated Angiosarcoma Presenting as Massive Pleural Effusion.

Hirokazu Ogino¹, Makoto Tobiume¹, Kozo Kagawa¹

¹Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan.

Internal Medicine (Tokyo, Japan)

|October 14, 2021

Summary

A patient with a history of radiation therapy developed radiation-associated angiosarcoma, a rare secondary cancer. Immunocytochemistry of pleural effusion aids in diagnosing this malignancy.

Keywords:

angiosarcoma cell block immunocytochemistry pleural effusion radiation associated sarcoma secondary cancer thoracoscopic pleural biopsy

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Area of Science:

Oncology
Pathology
Medical Imaging

Background:

A 67-year-old male patient presented with massive pleural effusion.
The patient had a prior history of mandibular gingival carcinoma treated with radiation therapy (RT).

Observation:

Diagnostic workup included thoracoscopic pleural biopsy and pleural effusion cytology.
Retrospective analysis utilized cell-block immunocytochemistry on pleural effusion samples.

Findings:

The patient was diagnosed with radiation-associated angiosarcoma.
Immunocytochemistry of pleural effusion demonstrated diagnostic utility.

Implications:

This case underscores the importance of considering secondary radiation-associated cancers in patients with pleural effusion post-radiation therapy.
Early recognition and diagnosis of radiation-associated angiosarcoma are crucial for patient management.