Related Experiment Video

Updated: Oct 17, 2025

Microscopic Cyst Resection for the Treatment of Patients Diagnosed with Epididymal Cyst
03:10

Microscopic Cyst Resection for the Treatment of Patients Diagnosed with Epididymal Cyst

Published on: March 31, 2023

9.3K

Castleman disease in the scrotum

Zhen Song1, Zhiyu Zhang1, Wenliang Xie1

  • 1Department of Urology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu, 215000, China.

Urology Case Reports
|October 14, 2021
PubMed

Insights

Castleman disease (CD), a rare lymphoproliferative disorder, has not been previously reported in the scrotum. This case highlights a 79-year-old man diagnosed with plasma cell type Castleman disease in the scrotum.

Area of Science:

  • Oncology
  • Pathology
  • Urology

Background:

  • Castleman disease is a rare lymphoproliferative disorder affecting lymph nodes.
  • Scrotal involvement by Castleman disease is undocumented in medical literature.

Observation:

  • A 79-year-old male presented with a painless, hard, enlarging right scrotal mass over one year.
  • Abdominopelvic CT revealed a 10 cm heterogeneously enhancing right scrotal mass.

Findings:

  • Surgical resection of the scrotal mass was performed.
  • Pathological diagnosis confirmed Castleman disease, specifically the plasma cell (PC) subtype.

Implications:

  • This case expands the known anatomical sites for Castleman disease.
  • It underscores the importance of considering rare diagnoses in scrotal masses.
  • Further research may be needed to understand the pathogenesis of extranodal Castleman disease.

Keywords:
Castleman diseaseIntrascrotal massPlasma cell type

More Related Videos

Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation03:19

Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation

Published on: August 30, 2024

957
A Modified Vessel-Sparing Microsurgical Vasoepididymostomy04:59

A Modified Vessel-Sparing Microsurgical Vasoepididymostomy

Published on: June 8, 2022

2.1K

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
2.4K
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
3.4K
Testes: Histology01:27

Testes: Histology

A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
1.7K
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
105.8K
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
352
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.9K