Allostatic Load, Mobility Disability, and Viral Effects in Cancer: A Structural Equation Model

Area of Science:

• Oncology
• Epidemiology
• Public Health

Background:

• Allostatic load reflects physiological stress responses, linked to increased morbidity, mortality, and cancer.
• Viruses cause 15-20% of cancers and can be activated by stress.
• Mobility limitations correlate with higher allostatic load and increased cancer risk.

Purpose of the Study:

• To investigate the relationship between cancer occurrence and three latent factors: allostatic load, physical functioning (mobility disability), and viral exposure.
• To test a conceptual model linking cancer outcomes with these key health variables.

Main Methods:

• Structural equation modeling was used to analyze data from 17,969 adult participants.
• Data were sourced from three National Health and Nutrition Examination Survey (NHANES) periods.
• A two-level model with three exogenous latent factors and one endogenous cancer factor was compared.

Main Results:

• The primary structural equation model demonstrated a strong fit (GFI = 0.948, RMSEA = 0.024).
• The model indicated significant associations between allostatic load, disability burden, and viral exposure/activation concerning cancer occurrence.
• A non-significant Chi-Square value further supported the robustness of the model.

Conclusions:

• The study suggests potential associations between physiological stress, mobility limitations, viral factors, and cancer incidence.
• Findings highlight the need for stress reduction and preventative health interventions.
• Additional support for individuals with disabilities and their caregivers is recommended.