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Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Background and Environment Affect Phenotype02:27

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Psychoneuroimmunology: Cardiovascular Disease01:27

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Regulation of the Cardiovascular System01:27

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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
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Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

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Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...
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Related Experiment Video

Updated: Oct 16, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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Gene-Environment Interactions for Cardiovascular Disease.

Jaana A Hartiala1, James R Hilser1,2, Subarna Biswas1,3

  • 1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, CSC202, Los Angeles, CA, 90033, USA.

Current Atherosclerosis Reports
|October 14, 2021
PubMed
Summary
This summary is machine-generated.

Gene-environment interactions influence cardiovascular disease (CVD) risk, primarily linked to smoking. Future research using large cohorts and advanced tools may uncover new genetic and environmental links to CVD.

Keywords:
Cardiovascular diseaseEnvironmental factorsGene-environment interactionsGeneticsGenome-wide association study

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Area of Science:

  • Genetics
  • Environmental Health
  • Cardiovascular Disease Research

Background:

  • Gene-environment (GxE) interactions are crucial for understanding cardiovascular disease (CVD) risk.
  • Previous research has primarily identified GxE interactions related to smoking and coronary artery disease (CAD).

Purpose of the Study:

  • To review recent findings on GxE interactions in CVD risk.
  • To discuss future research directions and opportunities in the field.

Main Methods:

  • Review of existing literature on GxE interactions for CVD.
  • Discussion of emerging methodologies and resources for future studies.

Main Results:

  • Limited evidence exists for GxE interactions with factors beyond smoking, including physical activity, air pollution, diet, and sex.
  • Large consortia, population-based cohorts, computational tools, and mouse genetics platforms show promise for future GxE studies.

Conclusions:

  • Identifying novel GxE interactions can enhance understanding of CVD pathogenesis and genetic susceptibility.
  • Findings have significant implications for promoting healthy lifestyles and developing therapeutic strategies for CVD.