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Fabricating Tissues In Situ with the Controlled Cellular Alignments.

Chuanjiang He1,2, Mengxue Liu1, Deming Jiang1

  • 1Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering, Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China.

Advanced Healthcare Materials
|October 14, 2021
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Summary

A novel "sewing-like" tissue engineering method precisely controls cellular alignment, creating functional skeletal muscle constructs in vitro and in vivo for effective tissue repair.

Keywords:
biomechanicscellular alignmentmuscle injurytissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Current tissue engineering methods struggle to replicate native tissue cellular arrangements, limiting physiological relevance.
  • Precise cellular alignment is crucial for the function of many tissues, including skeletal muscle.

Purpose of the Study:

  • To develop a novel fabrication method for controlling cellular alignment in engineered tissues.
  • To assess the efficacy of this method in creating functional skeletal muscle constructs.
  • To explore the in vivo application of this technique for tissue repair.

Main Methods:

  • A "sewing-like" fabrication process integrating a stretching step to create a static mechanical environment.
  • Mechanical induction of myoblast fusion and maturation for skeletal muscle construct development.
  • In vivo application of aligned myofiber fabrication onto injured muscle tissue.

Main Results:

  • The method enables the fabrication of patterned cellular constructs with controlled cellular alignment.
  • Physiologically relevant skeletal muscle constructs were successfully engineered in vitro.
  • Effective repair of damaged muscle tissue was achieved through in vivo fabrication of aligned myofibers.

Conclusions:

  • The "sewing-like" method offers precise control over cellular arrangements in engineered tissues.
  • This technique yields engineered tissues with enhanced clinical viability and functionality.
  • The method holds significant potential for advancing regenerative medicine and tissue repair strategies.