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Platelet dimensions in pregnancy-induced hypertension
The New Zealand Medical Journal
|May 28, 1986
Summary
Mean platelet volume (MPV) and platelet distribution width (PDW) are elevated in women with pregnancy-induced hypertension. These platelet indices may serve as useful diagnostic markers for this condition.
Area of Science:
- Obstetrics and Gynecology
- Hematology
Background:
- Pregnancy-induced hypertension (PIH) is a significant complication of pregnancy.
- Accurate and early diagnosis of PIH is crucial for maternal and fetal well-being.
Purpose of the Study:
- To investigate the utility of platelet parameters, specifically platelet number, mean platelet volume (MPV), and platelet distribution width (PDW), in diagnosing PIH.
- To compare these parameters between women with PIH and normotensive pregnant women.
Main Methods:
- Platelet count, MPV, and PDW were measured in 55 women diagnosed with PIH.
- Diagnostic criteria for PIH included sustained diastolic blood pressure >90 mmHg, normal first-trimester blood pressure, and plasma urate >0.34 mmol/l.
- Data were compared with a control group of 96 normotensive women matched for gestational length.
Main Results:
- Women with PIH exhibited significantly higher MPV and PDW compared to the normotensive control group.
- No significant difference was observed in platelet numbers between the two groups.
Conclusions:
- Elevated MPV and PDW are associated with pregnancy-induced hypertension.
- MPV and PDW measurements can be valuable diagnostic indicators for PIH.