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Increased Incidence of Mental Disorders in Children with Cataract: Findings from a Population-based Study
Moug Al-Bakri1, Anne Mette Skovgaard2, Daniella Bach-Holm3
1From the Department of Ophthalmology, Rigshospitalet (M.A.-L., D.B.-HH, L.K.).
Insights
Children with cataract have nearly double the incidence of mental disorders, with higher risks for anxiety and developmental delay. Early diagnosis before age 3 significantly increases this risk.
Area of Science:
- Ophthalmology
- Child Psychiatry
- Epidemiology
Background:
- Cataract in childhood can impact development.
- Understanding the link between childhood cataract and mental health is crucial for early intervention.
Purpose of the Study:
- To investigate the incidence of mental disorders in children with cataract compared to those without.
- To identify specific mental health risks associated with childhood cataract.
Main Methods:
- A nationwide cohort study utilized comprehensive national databases.
- Compared children diagnosed with cataract before age 10 to sex- and age-matched controls.
- Adjusted analyses for somatic diseases, parental socioeconomic status, and psychiatric history.
Main Results:
- Children with cataract had a nearly doubled incidence of mental disorders (OR, 1.83).
- Quadrupled risk of anxiety disorders (OR, 4.10) and doubled risk of developmental delay (OR, 2.66).
- Increased risk was most pronounced in children diagnosed within the first 3 years of life (OR, 2.36).
Conclusions:
- Childhood cataract is associated with a significantly increased risk of mental disorders, particularly anxiety and neurodevelopmental delay.
- Early diagnosis of cataract (within the first 3 years) further elevates this risk.
- Integrating psychiatric screening into the management of children with cataract is recommended.
Purpose:
To examine the incidence of mental disorders in children with cataract compared with children without cataract.
Design:
Nationwide cohort study based on entries in comprehensive national databases.
Methods:
The incidence of mental disorders in children born between 2000 and 2017 diagnosed with cataract before 10 years of age (n = 485) was compared with sex- and age-matched controls (n = 4358). Analyses were corrected to somatic disease in the child and parental socioeconomic status and psychiatric morbidity. The study was conducted as 2 university hospitals in Denmark managing children 6 years of age our younger with cataract.
Results:
The incidence of mental disorders was nearly doubled in children with cataract compared with controls (odds ratio [OR], 1.83; 95% CI, 1.28-3.63). The risk of anxiety disorders was quadrupled (OR, 4.10; 95% CI, 1.90-8.84) and the risk of developmental delay was doubled (OR, 2.66; 95% CI, 1.45-4.90). The risk of mental disorders was significantly higher in children diagnosed with cataract in the first 3 years of life compared with controls (OR, 2.36; 95% CI, 1.53-3.64), whereas those diagnosed with cataract later in childhood did not have an increased risk (OR, 1.24; 95% CI, 0.66-2.30).
Conclusions:
The risk of mental disorders, in particular anxiety and neurodevelopmental delay, is markedly increased in children with cataract and even more so in those diagnosed within the first 3 years of life. Psychiatric screening instruments may be integrated in the management of these children.
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