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Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives
Hardeep Singh Tuli1, Ruchira Joshi2, Diwakar Aggarwal1
1Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.
Abstract:
Despite extensive efforts, cancer is still often considered as an incurable disease and initiation of novel drug development programs is crucial to improve the prognosis and clinical outcome of patients. One of the major approaches in designing the novel cancer drugs has historically comprised studies of natural agents with diverse anticancer properties. As only a marginal part of natural compounds has been investigated, this approach still represents an attractive source of new potential antitumor molecules. In this review article, different anticancer effects of plant-derived chalcone, butein, are discussed, including its growth inhibitory action, proapoptotic, antiangiogenic and antimetastatic activities in a variety of cancer cells. The molecular mechanisms underlying these effects are presented in detail, revealing interactions of butein with multiple cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R etc.) and regulation of a wide range of intracellular signal transduction pathways. These data altogether allow a good basis for initiating further in vivo studies as well as clinical trials. Along with the efforts to overcome low bioavailability issues generally characteristic to plant metabolites, butein can be considered as a potential lead compound for safe and more efficient cancer drugs in the future.
Insights
Butein, a plant-derived compound, exhibits significant anticancer properties including growth inhibition, apoptosis induction, and antiangiogenic effects. Further research into butein could lead to novel, safer cancer therapeutics.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Oncology
Background:
- Cancer remains a significant global health challenge, necessitating novel therapeutic strategies.
- Natural products offer a rich source for discovering new anticancer agents.
- Butein, a chalcone from plants, has shown potential anticancer activities.
Purpose of the Study:
- To review the diverse anticancer effects of butein.
- To elucidate the molecular mechanisms underlying butein's antitumor activities.
- To assess butein's potential as a lead compound for future cancer drug development.
Main Methods:
- Literature review of studies on butein's anticancer effects.
- Analysis of butein's interactions with key cellular targets.
- Examination of butein's impact on various cancer cell signaling pathways.
Main Results:
- Butein demonstrates growth inhibitory, pro-apoptotic, antiangiogenic, and antimetastatic activities.
- Butein interacts with multiple targets including Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, and VEGF/R.
- Butein modulates a wide array of intracellular signal transduction pathways.
Conclusions:
- Butein exhibits multifaceted anticancer properties with detailed molecular mechanisms identified.
- Butein shows promise as a potential lead compound for developing novel and safer cancer drugs.
- Further in vivo studies and clinical trials are warranted to explore butein's therapeutic potential.
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