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Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent
Grant A Challen1, Eric M Pietras2, Nina Cabezas Wallscheid3
1Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Experimental Hematology
|October 14, 2021
Summary
Researchers propose a unified definition for murine multipotent progenitors (MPPs) to reduce confusion in hematology research. This simplified scheme aids comparison of MPP populations across studies.
Area of Science:
- Hematology
- Developmental Biology
- Immunophenotyping
Background:
- The mouse hematopoietic system is a key model for studying cell development, homeostasis, and regeneration.
- Inconsistent definitions and nomenclature for murine multipotent progenitors (MPPs) create confusion in the field.
- Difficulty in comparing MPP populations across studies hinders research progress.
Purpose of the Study:
- To develop a simplified and unified immunophenotypic definition for murine multipotent progenitors (MPPs).
- To address the confusion caused by divergent MPP classifications in experimental hematology.
- To facilitate consistent comparison of MPP phenotypes between research laboratories.
Main Methods:
- A working group of International Society for Experimental Hematology (ISEH) members reviewed existing literature.
- Consultation with leaders in the field and crowdsourcing from the experimental hematology community were employed.
- A position statement was developed and presented to the ISEH community for feedback.
Main Results:
- A simplified MPP Identification Scheme has been proposed.
- The scheme aims to unify the immunophenotypic definition of MPP populations.
- The proposed scheme allows for individual investigator customization.
Conclusions:
- Adoption of a unified MPP definition and nomenclature will benefit the hematology research community.
- Standardized definitions will improve the comparability of MPP populations across experimental settings.
- This initiative promotes consistency and reduces ambiguity in studying hematopoietic development.
