Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

319
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
319
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

1.1K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
1.1K
Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

Oxygen Delivering System I: Nasal Cannula and Face Mask

740
The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
740
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

374
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
374

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolving together: Dynamic transactions of antagonistic and self-centered traits with couple relationships.

Journal of personality and social psychology·2026
Same author

L-type pyocins inhibit the BAM complex to kill without cell entry.

Nature communications·2026
Same author

Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain.

bioRxiv : the preprint server for biology·2026
Same author

Nitric oxide-releasing balloon inflation fluid for Foley catheters to prevent catheter-associated urinary tract infections.

Microbiology spectrum·2026
Same author

Motor evoked potentials as markers of internal capsule current spread during deep brain stimulation for Parkinson's disease.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Prefrontal cortical pathways mediating cognitive control enhancement from internal capsule stimulation.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Oct 16, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.3K

A pumpless artificial lung without systemic anticoagulation: The Nitric Oxide Surface Anticoagulation system.

Brian P Fallon1, Orsolya Lautner-Csorba1, Alex J Thompson1

  • 1Extracorporeal Life Support Laboratory, Department of Surgery, Michigan Medicine, B560 MSRB II/SPC 5686, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.

Journal of Pediatric Surgery
|October 15, 2021
PubMed
Summary

The Nitric Oxide (NO) Surface Anticoagulation (NOSA) system effectively anticoagulates a pumpless artificial lung for 24 hours. This novel system achieves NO flux comparable to native endothelium, offering a promising alternative for pediatric patients.

Keywords:
Artificial lungBiocompatibilityExtracorporeal life supportExtracorporeal membrane oxygenationNon-thrombogenic circuitsPediatric respiratory failure

More Related Videos

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting
08:53

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

540
Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.2K

Related Experiment Videos

Last Updated: Oct 16, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.3K
Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting
08:53

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

540
Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.2K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Pediatric Critical Care

Background:

  • Artificial lungs are vital for children with end-stage lung disease, but require systemic anticoagulation.
  • The novel Nitric Oxide (NO) Surface Anticoagulation (NOSA) system aims to overcome this limitation.
  • This study evaluates the NOSA system with the Pediatric MLung, a low-resistance, pumpless artificial lung.

Purpose of the Study:

  • To assess the NO flux of the NOSA system across the Pediatric MLung membrane.
  • To evaluate the efficacy of the NOSA system in providing local anticoagulation in a pumpless artificial lung circuit.
  • To determine the safety and performance of the NOSA system in a preclinical model.

Main Methods:

  • NO flux testing was performed on MLungs under veno-venous extracorporeal life support in sheep.
  • Pumpless implants involved cannulating sheep and connecting them to the MLung with NO-releasing components for 24 hours.
  • Measurements included NO/NO2 levels, blood flow, oxygen saturation, activated clotting time, and platelet counts.

Main Results:

  • NO flux averaged 3.4 flux units, comparable to human vascular endothelium.
  • Three sheep survived 24 hours with patent circuits, maintaining MLung blood flow of 716 mL/min and 98.3% oxygen saturation.
  • Activated clotting time remained elevated, but platelet counts decreased without significant activation, indicating localized anticoagulation.

Conclusions:

  • The NOSA system effectively generates NO flux across the artificial lung membrane.
  • The system provides 24-hour local anticoagulation for the artificial lung circuit.
  • This technology presents a potential advancement for extracorporeal life support in pediatric patients.