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Updated: Oct 16, 2025

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
How to reduce uncommon but severe transcatheter aortic valve implantation complications: stroke, thrombosis,
Francesco Saia1, Mateusz Orzalkiewicz1
1Cardiac Unit, Cardio-Thoracic-Vascular Department, IRCCS University Hospital of Bologna, Policlinico S. Orsola (Pav. 23), Via Massarenti, 9, 40138 Bologna, Italy.
Insights
Transcatheter aortic valve implantation (TAVI) is a safe alternative for severe aortic stenosis. This review details uncommon TAVI complications like stroke and endocarditis, focusing on prevention.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- Transcatheter aortic valve implantation (TAVI) is a primary treatment for severe symptomatic aortic stenosis.
- TAVI offers a less invasive alternative to surgical aortic valve replacement, suitable for all surgical risk levels.
- Improvements in technology and operator experience have reduced TAVI's periprocedural complication rates.
Purpose of the Study:
- To review uncommon but severe complications following TAVI.
- To discuss the incidence, risk factors, and prevention strategies for these delayed complications.
Main Methods:
- Literature review focusing on post-TAVI complications.
- Analysis of incidence, predictive factors, and preventive measures for stroke, infective endocarditis, valve thrombosis, and cognitive decline.
Main Results:
- While periprocedural complications have decreased, uncommon events like stroke, endocarditis, valve thrombosis, and cognitive decline can occur post-TAVI.
- These complications may manifest during follow-up but can also arise periprocedurally.
- Identification of predictive factors and preventive strategies is crucial for patient management.
Conclusions:
- TAVI is a well-established procedure with declining complication rates.
- Awareness and proactive management of uncommon delayed complications are essential for optimizing long-term TAVI outcomes.
- Further research into predictive factors and preventive strategies for these rare events is warranted.
Abstract:
Transcatheter aortic valve implantation has become a valid alternative to surgical aortic valve replacement for patients with symptomatic severe aortic stenosis, regardless of baseline surgical risk. The incidence of periprocedural complications has steadily declined over the years, thanks to technical advancement of transcatheter heart valves, delivery systems, and increased operators' experience. Beyond the most common periprocedural complications, there are a few uncommon but potentially severe complications that more often occur during follow-up, although they may also arise in the periprocedural phase. Stroke, infective endocarditis, valve thrombosis, and cognitive decline are among them. In this brief review, we describe the incidence, predictive factors, and potential preventive measures for those events.
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