Related Experiment Video

Updated: Oct 16, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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Sirtuin Modulators in Cellular and Animal Models of Human Diseases

Jun Young Hong1, Hening Lin1,2

  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, United States.

Frontiers in Pharmacology
|October 15, 2021
PubMed

Insights

Sirtuins are enzymes that regulate key cell functions and are implicated in diseases like cancer. This review summarizes genetic and drug-based approaches to modulate sirtuins for treating cancer, neurological, and cardiovascular conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Sirtuins are NAD+-dependent enzymes removing acyl groups from proteins.
  • They regulate crucial cellular processes like proliferation, metabolism, and migration.
  • Seven human sirtuins (SIRT1-7) exhibit distinct activities and roles.

Purpose of the Study:

  • To review genetic and pharmacological modulation of sirtuins.
  • Focus on sirtuins' roles in cancer, neurological, and cardiovascular diseases.
  • To highlight the significance of sirtuins in disease pathology.

Main Methods:

  • Literature review of genetic modifications affecting sirtuins.
  • Analysis of pharmacological agents targeting sirtuin activity.
  • Synthesis of findings related to sirtuin modulation in specific diseases.

Main Results:

  • Sirtuins are implicated in cancer, neurodegeneration, and cardiovascular diseases.
  • Genetic and pharmacological strategies offer therapeutic potential.
  • Modulation impacts cell proliferation, genome stability, and metabolism.

Conclusions:

  • Sirtuins are critical targets for therapeutic intervention.
  • Understanding sirtuin modulation is key for treating major human diseases.
  • Further research into sirtuin modulators is warranted.
Keywords:
SIRT1SIRT2activatorcancercardiovacsular diseasesinhibitorneurodeganarationsirtuin

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