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Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease
1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Frontiers in Endocrinology
|October 15, 2021
Summary
Chronic obstructive pulmonary disease (COPD) is linked to sarcopenia and osteoporosis. Muscle-bone crosstalk involving myokines and osteokines may explain these common comorbidities in COPD patients.
Area of Science:
- Biomedical Science
- Endocrinology
- Pulmonology
Background:
- Sarcopenia and osteoporosis are frequent in chronic obstructive pulmonary disease (COPD), impacting patient prognosis and quality of life.
- Muscle and bone act as endocrine organs, producing myokines and osteokines that influence their respective functions and metabolism.
- Myokines like irisin and myostatin, and osteokines such as receptor activator of nuclear factor kappa-B ligand (RANKL), are implicated in muscle and bone health.
Purpose of the Study:
- To review the role of myokines and osteokines in the pathogenesis of skeletal muscle dysfunction and osteoporosis in COPD.
- To explore muscle-bone crosstalk as a key mechanism for the co-occurrence of muscle and bone diseases in COPD.
Main Methods:
- Literature review focusing on myokines, osteokines, and their involvement in COPD-related musculoskeletal conditions.
- Analysis of evidence linking specific myokines (irisin, myostatin, IL-6) and osteokines (RANKL) to sarcopenia and osteoporosis in COPD.
Main Results:
- Irisin, myostatin, and IL-6 are dysregulated in COPD and associated with skeletal muscle dysfunction and bone loss.
- IL-6, a myokine highly expressed in COPD, acts as a biomarker for systemic inflammation linked to sarcopenia and osteoporosis.
- RANKL, an osteokine, plays a role in skeletal muscle atrophy induced by chronic cigarette smoke exposure.
Conclusions:
- Myokines and osteokines are crucial in the development of sarcopenia and osteoporosis in COPD patients.
- Muscle-bone crosstalk represents a significant mechanism underlying the concurrent muscle and bone pathologies observed in COPD.
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