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Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

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The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
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Law of Independent Assortment02:03

Law of Independent Assortment

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While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.
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Dihybrid Crosses01:18

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Monohybrid Crosses01:20

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Epistasis Analysis01:09

Epistasis Analysis

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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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Law of Segregation01:49

Law of Segregation

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When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
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Related Experiment Video

Updated: Oct 16, 2025

Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast
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Editorial: Mendelian Randomization: Approach and Applications

Guo-Liang Wu1, Yao-Zhong Liu2, Lei Zhang3

  • 1Department of General Surgery, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China.

Frontiers in Genetics
|October 15, 2021
PubMed
Summary

No abstract available in PubMed .

Keywords:
Mendelian randomizationcausal inferenceconfounding factorgenome-wide association studyhorizontal pleiotropy

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