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Updated: Oct 16, 2025
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Evaluation of left ventricular function in patients with heart failure after myocardial infarction by real-time
1Department II of Ultrasound, Cangzhou Central Hospital Cangzhou, China.
Insights
Serum biomarkers cardiac troponin I (cTnI) and heart-type fatty acid-binding protein (H-FABP) correlate with left ventricular function in heart failure patients post-myocardial infarction, aiding early diagnosis.
Area of Science:
- Cardiology
- Biomarkers
- Echocardiography
Background:
- Heart failure (HF) post-myocardial infarction (MI) significantly impacts left ventricular (LV) function.
- Early and accurate assessment of LV function is crucial for managing HF patients.
Purpose of the Study:
- To evaluate LV function in HF patients post-MI using real-time three-dimensional transesophageal echocardiography (RT-3D-TEE).
- To explore the correlation between LV function parameters and serum levels of cardiac troponin I (cTnI) and heart-type fatty acid-binding protein (H-FABP).
Main Methods:
- Retrospective analysis of 60 HF patients post-MI and 50 healthy controls.
- Measurements included left atrial diameter, septal and posterior wall thickness, LV volumes, and ejection fraction (LVEF) via RT-3D-TEE.
- Serum cTnI and H-FABP levels were determined using ELISA.
Main Results:
- HF patients exhibited impaired LV structure and function, with elevated serum cTnI and H-FABP compared to controls.
- Cardiac function grade correlated positively with LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), cTnI, and H-FABP, and negatively with LVEF.
- Serum cTnI and H-FABP levels correlated with LV volumes and LVEF, with both identified as risk factors for HF, while LVEF was protective.
Conclusions:
- Serum cTnI and H-FABP levels are closely related to LV function parameters in HF patients.
- Combining RT-3D-TEE with serum biomarker analysis (cTnI, H-FABP) offers significant clinical value for the early diagnosis of HF.
Objective:
To evaluate the left ventricular function in patients with heart failure (HF) after myocardial infarction (MI) by real-time three-dimensional transesophageal echocardiography (RT-3D-TEE) and explore its correlation with serum cTnI and H-FABP levels.
Methods:
The data of 60 HF patients after MI from March 2019 to January 2021 were analyzed retrospectively and included in the research group. According to cardiac function grades, they were assigned to group A (20 cases), group B (20 cases), and group C (20 cases). During the same period, 50 healthy patients were included in the control group. The left atrial diameter (LAD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular stroke volume (LVSV), and left ventricular ejection fraction (LVEF) of participants were recorded and compared in the four groups. The serum levels H-FABP and cTnI were tested by ELISA.
Results:
HF patients had poorer left heart structure and lower function and higher serum H-FABP and cTnI levels, as compared to the subjects in control group. Correlation analysis indicated that the cardiac function grade was positively correlated with LVEDV, LVESV, H-FABP, and cTnI, but negatively correlated with LVEF. The serum H-FABP and cTnI levels of HF patients were positively correlated with LVEDV and LVESV, but negatively correlated with LVEF. Logistic regression analysis revealed that cTnI and H-FABP were risk factors for HF, and LVEF was a protective factor for HF.
Conclusion:
Serum H-FABP and cTnI levels in HF patients are correlated with left ventricular function parameters, which presents a close relation to HF. RT-3D-TEE combined with the detection of serum H-FABP and cTnI yields important clinical significance for early diagnosis of HF.
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