A modified source-detector configuration for the discrimination between normal and diseased human breast based on the...

Area of Science:

• Biomedical Optics
• Medical Imaging
• Cancer Diagnostics

Background:

• Breast tumors are prevalent, necessitating early detection for effective treatment.
• Current screening methods like PET, MRI, and mammography have limitations, including cost, time, and age restrictions.
• Diffuse optical imaging presents a safe, non-invasive alternative using near-infrared light.

Purpose of the Study:

• To propose a modified diffuse optical imaging arrangement for improved breast tumor detection.
• To develop and simulate a 3D breast model for estimating optical properties.
• To identify the optimal wavelength for differentiating tumors from healthy breast tissue.

Main Methods:

• A 3D finite element model of the human breast with tumors was developed using COMSOL.
• Near-infrared light interaction with different breast tissue layers was simulated.
• Various wavelengths were tested to assess their efficacy in tumor detection.
• The receiver operating characteristic (ROC) method was used for result verification.

Main Results:

• Simulations demonstrated distinct optical fluence distributions between normal and tumor-affected breast tissue.
• The 600-nm incident laser wavelength showed significant potential for tumor discrimination.
• ROC curve analysis confirmed the effectiveness of the proposed method.

Conclusions:

• The modified diffuse optical imaging technique, particularly at 600 nm, offers a promising approach for non-invasive breast tumor detection.
• This method provides a valuable alternative to conventional screening, especially for specific patient groups.
• Further research can optimize this technique for clinical application.