Related Experiment Video
Updated: Oct 16, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Spike protein evolution in the SARS-CoV-2 Delta variant of concern: a case series from Northern Lombardy
Andreina Baj1,2, Federica Novazzi1, Francesca Drago Ferrante1
1Laboratory of Microbiology, ASST Sette Laghi, Varese, Italy.
Abstract:
The SARS-CoV-2 variant of concern (VOC) "Delta" is currently defined by PANGOLIN as a cluster of 33 different AY sublineages. Delta (in particular B.1.617.2) is largely and rapidly replacing the Alpha VOC as the dominant clade in most countries. To date, variations in the Spike protein of the Delta VOC have largely been limited. We report here the results of a genomic surveillance programme from Northern Italy. We identified several Delta sublineages harbouring mutations previously reported in GISAID at extremely low frequencies and in different combinations. Two patients (one of them vaccinated) tested positive for a Delta sublineage harbouring S71F, T250I, T572I and K854N. More patients tested positive for G769 V plus C1248F, A352S, and R158G and C1248F, respectively. Genomic surveillance of Delta variants should be encouraged to anticipate immune escape and deploy countermeasures.
More Related Videos
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Viral Mutations
Leaky Scanning

