Related Experiment Video
Updated: Oct 16, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
Published on: February 3, 2023
Directed genome evolution driven by structural rearrangement techniques
Sijie Zhou1,2, Yi Wu1,2, Ze-Xiong Xie1,2
1Frontier Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, 300072, China. yjyuan@tju.edu.cn.
Abstract:
Directed genome evolution simulates the process of natural evolution at the genomic level in the laboratory to generate desired phenotypes. Here we review the applications of recent technological advances in genome writing and editing to directed genome evolution, with a focus on structural rearrangement techniques. We highlight how these techniques can be used to generate diverse genotypes, and to accelerate the evolution of phenotypic traits. We also discuss the perspectives of directed genome evolution.
Related Concept Videos
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Gene Conversion
Evolutionary Relationships through Genome Comparisons
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Genome Size and the Evolution of New Genes

