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Cytophagic panniculitis.

L M March, J Webb, R P Eckstein

    Australian and New Zealand Journal of Medicine
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    A 60-year-old woman presented with erythema nodosum-like lesions, fever, and hepatitis. Her condition, characterized by lobular panniculitis with histiocytic infiltrate and phagocytosis, responded to corticosteroids, suggesting cytophagic panniculitis or virus-associated hemophagocytic syndrome.

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    Area of Science:

    • Dermatology
    • Pathology
    • Immunology

    Background:

    • Erythema nodosum-like lesions can manifest in various systemic conditions.
    • Lobular panniculitis with histiocytic infiltrate and phagocytosis presents a diagnostic challenge.

    Observation:

    • A 60-year-old woman developed generalized erythema nodosum-like lesions, fever, lymphadenopathy, and hepatitis.
    • Subcutaneous biopsies, lymph nodes, and bone marrow revealed lobular panniculitis with benign histiocytic infiltrate and prominent phagocytosis.
    • Herpes simplex was isolated from the throat, but other immunological and serological studies were negative.

    Findings:

    • The patient's presentation and biopsy findings were consistent with cytophagic panniculitis or virus-associated hemophagocytic syndrome.
    • High-dose corticosteroid therapy led to a positive clinical response.

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    Implications:

    • This case highlights the importance of considering cytophagic panniculitis and virus-associated hemophagocytic syndrome in the differential diagnosis of lobular panniculitis.
    • Early recognition and appropriate management, including corticosteroid therapy, can improve patient outcomes.