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High affinity associations with α-SNAP enable calcium entry via Orai1 channels

Ramanagouda Ramanagoudr-Bhojappa1, Yong Miao2, Monika Vig3

  • 1Cancer Genetics and Comparative Genomics Branch, NHGRI, Bethesda, MD, United States of America.

Plos One
|October 15, 2021
PubMed
Summary

Alpha-SNAP (soluble NSF attachment protein) is crucial for store-operated calcium entry (SOCE). It binds Orai1 and Stim1 channels with high affinity, enabling their functional assembly and calcium influx.

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