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Updated: Oct 16, 2025

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Case Series: Hypercalcemia From Granulomatous Silicosis Developing After COVID-19 Infection
Ashley Bray1, Jonathan Vincent M Reyes1, Nancy Tarlin2
1Department of Internal Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Abstract:
Hypercalcemia is one of the most commonly encountered laboratory abnormalities in clinical medicine. Various causes have been well established. However, it is likely that the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may be a newly found cause of this frequent finding, especially amongst those with a history of cosmetic surgery, specifically by means of silicone injection. In this case series, we describe 2 patients presenting with symptomatic hypercalcemia likely from their prior silicone injections. Interestingly, each patient only developed symptoms of hypercalcemia following infection with SARS-CoV-2.
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