Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers.

Area of Science:

• Oncology
• Immunology
• Molecular Biology

Background:

• Tumor cells exhibit altered metabolism that fuels growth and creates an immunosuppressive microenvironment.
• Noncoding RNAs (ncRNAs) regulate cellular processes and can bridge metabolic activity with immune responses.
• microRNAs, long noncoding RNAs (lncRNAs), and circRNAs are implicated in tumor metabolic reprogramming and immune cell modulation.

Purpose of the Study:

• To summarize the role of ncRNAs in remodeling tumor metabolism and the immune microenvironment.
• To introduce TIMELnc, a manual for identifying lncRNAs associated with tumor metabolism and immune infiltration.

Main Methods:

• Literature review on ncRNAs in cancer metabolism and immunity.
• Bioinformatic approach to identify pivotal lncRNAs.
• Development of the TIMELnc manual.

Main Results:

• Noncoding RNAs play a significant role in regulating tumor metabolic reprogramming.
• ncRNAs influence immune cell infiltration and function within the tumor microenvironment.
• The TIMELnc manual provides a resource for identifying key lncRNAs connecting tumor metabolism and immune infiltration.

Conclusions:

• Noncoding RNAs are critical regulators of the interplay between tumor metabolism and the immune microenvironment.
• The TIMELnc manual serves as a valuable tool for researchers investigating these complex relationships.
• Understanding these ncRNA roles can inform novel therapeutic strategies targeting cancer metabolism and immunity.