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Childhood lung function as a determinant of menopause-dependent lung function decline.
Kai Triebner1, Dinh Bui2, Eugene Haydn Walters2
1Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway; Core Facility for Metabolomics, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway.
Maturitas
|October 16, 2021
Summary
Women with poorer childhood lung function experience accelerated lung function decline after menopause. This highlights the importance of lifelong respiratory health strategies for women.
Area of Science:
- Reproductive Health
- Pulmonary Medicine
- Longitudinal Cohort Studies
Background:
- Age-dependent lung function decline accelerates post-menopause, linked to endocrine shifts.
- Early-life lung health impacts adult susceptibility to respiratory insults.
- The effect of childhood lung function on menopause-related decline is unknown.
Purpose of the Study:
- To investigate if childhood lung function predicts menopause-dependent decline in lung function.
- To assess the relationship between early lung health and respiratory aging in women.
Main Methods:
- Utilized the Tasmanian Longitudinal Health Study (cohort born 1961).
- Collected spirometry at age seven, and at ages 45 & 50 with hormone assays and questionnaires (N=506).
- Analyzed menopause-dependent lung function decline (FVC, FEV1) using linear mixed models, stratified by childhood lung function tertiles.
Main Results:
- Overall menopause-dependent decline observed for FVC (19.3 mL/y) and FEV1 (9.1 mL/y).
- This decline was significantly more pronounced in women with the lowest tertile of childhood lung function (FVC 22.2 mL/y, FEV1 13.9 mL/y).
Conclusions:
- Postmenopausal women with poor childhood lung function exhibit accelerated lung function decline.
- Findings offer new insights into respiratory health during reproductive aging.
- Emphasizes the need for comprehensive, lifespan-focused public health strategies for respiratory wellness.
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