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Related Concept Videos

Nociception01:44

Nociception

30.8K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Updated: Oct 16, 2025

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
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Decrease in pain perception during acute SARS-CoV-2 infection: a case series.

Lisa Hentsch1, Patrick Stancu2, Gilles Allali2,3

  • 1Division of Palliative Medicine, Geneva University Hospitals, Geneva, Switzerland.

Pain
|October 16, 2021
PubMed
Summary
This summary is machine-generated.

This study observed that three cancer patients experienced reduced or eliminated chronic pain during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Pain returned after COVID-19 recovery, suggesting a novel link between infection and pain perception.

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Pain Medicine

Background:

  • Numerous reports link severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to new-onset or increased chronic pain.
  • The neurological and physiological impact of SARS-CoV-2 on pain pathways remains incompletely understood.

Purpose of the Study:

  • To report a unique observation of acute pain reduction in patients with chronic cancer pain during SARS-CoV-2 infection.
  • To investigate the potential modulatory effects of SARS-CoV-2 on chronic pain perception.

Main Methods:

  • Case series describing three patients with pre-existing chronic cancer pain.
  • Clinical observation of pain levels before, during, and after SARS-CoV-2 infection.
  • Review of available neurological imaging and pathological findings.

Main Results:

  • All three patients experienced a significant reduction or complete disappearance of chronic cancer pain during their SARS-CoV-2 infection.
  • Pain perception returned to baseline levels after recovery from SARS-CoV-2 infection.
  • Neurological and pathological findings were inconclusive in explaining the observed pain modulation.

Conclusions:

  • This case series presents the first reported instances of acute pain reduction associated with SARS-CoV-2 infection.
  • The findings suggest SARS-CoV-2 may acutely modulate pain perception, warranting further investigation into underlying mechanisms.
  • Understanding this phenomenon could offer new insights into pain modulation and treatment strategies.