Related Experiment Video
Updated: Oct 16, 2025
03:52
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
600
Relationship between chronic kidney disease and sarcopenia.
Ming-Dian Yu1, Hui-Zhen Zhang2, Yu Zhang1
1Department of Nuclear Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134. Dongjie Street, Fuzhou, 350001, China.
Scientific Reports
|October 16, 2021
Summary
Chronic kidney disease (CKD) is linked to sarcopenia, a condition of muscle loss. Muscle mass and function decline with CKD progression, increasing sarcopenia risk in patients.
Area of Science:
- Nephrology
- Geriatrics
- Muscle Physiology
Background:
- Sarcopenia, characterized by muscle loss and weakness, is prevalent in older adults.
- The association between chronic kidney disease (CKD) and sarcopenia, particularly in mild to moderate renal decline, remains under-investigated.
- Understanding this relationship is crucial for managing comorbidities in CKD patients.
Purpose of the Study:
- To investigate the relationship between chronic kidney disease (CKD) and sarcopenia.
- To determine if CKD progression is an independent risk factor for sarcopenia.
- To compare sarcopenia prevalence in CKD patients versus healthy individuals.
Main Methods:
- Cross-sectional study involving 123 hospitalized CKD patients and 57 healthy controls.
- Body composition assessed using dual-energy X-ray absorptiometry (DXA) to calculate relative appendicular skeletal muscle index (RASMI).
- Muscular strength measured via hand dynamometry; muscular function assessed by 6-meter walking speed; glomerular filtration rate (GFR) determined by SPECT.
Main Results:
- RASMI demonstrated a significant downward trend with advancing CKD stages (P=0.001).
- Age and CKD progression were identified as independent risk factors for sarcopenia through multivariate logistic regression.
- Sarcopenia prevalence was significantly higher in CKD patients compared to healthy volunteers, with muscle loss correlating with CKD severity.
Conclusions:
- CKD progression is significantly associated with increased sarcopenia risk.
- Muscle loss and functional decline are closely related to the severity of chronic kidney disease.
- These findings highlight the importance of monitoring muscle health in CKD patients.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
167
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
167
01:24Chronic Kidney Disease II: Clinical Manifestations
159
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
159
01:28Chronic Kidney Disease III: Interprofessional Care
124
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
124
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
65
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
65
01:18Chronic Kidney Disease IV: Nursing Management
87
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
87
01:24Nephrotic Syndrome I : Introduction
113
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
113