Related Experiment Video

Updated: Oct 16, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

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A comprehensive review of the impact of obesity on plasma cell disorders

Richa Parikh1, Syed Maaz Tariq2, Catherine R Marinac3

  • 1Myeloma Center, Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Leukemia
|October 16, 2021
PubMed

Insights

Obesity is linked to multiple myeloma (MM) development and prognosis. Lifestyle changes may reduce MM incidence and improve outcomes in high-risk individuals.

Area of Science:

  • Oncology
  • Metabolic Syndrome

Background:

  • Multiple myeloma (MM) is an incurable plasma cell cancer.
  • Metabolic risk factors, including obesity, are associated with cancer development.
  • The precise role of obesity in MM pathogenesis and prognosis requires further elucidation.

Purpose of the Study:

  • To review the impact of obesity on multiple myeloma pathogenesis.
  • To examine obesity's influence on MM patient outcomes.
  • To discuss potential mechanisms linking obesity to MM risk and prognosis.

Main Methods:

  • Literature review and synthesis of existing research on obesity and multiple myeloma.
  • Analysis of data on MM risk, progression, and survival in relation to obesity.
  • Discussion of proposed biological pathways connecting metabolic factors to MM.

Main Results:

  • Obesity is associated with increased risk and potentially poorer outcomes in multiple myeloma patients.
  • Several mechanisms are proposed, including chronic inflammation, altered immune function, and hormonal changes.
  • Modifiable lifestyle factors, particularly weight management, may play a significant role.

Conclusions:

  • Obesity is a critical factor influencing multiple myeloma development and patient prognosis.
  • Further clinical trials are needed to evaluate lifestyle interventions for MM prevention and management.
  • Evidence-based lifestyle recommendations could improve MM control in at-risk populations.

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