The pediatric urobiome in genitourinary conditions: a narrative review

Area of Science:

• Pediatric Urology
• Microbiome Research
• Genitourinary Health

Background:

• The urinary microbiome (urobiome) is an emerging research area.
• Limited data exists on the pediatric urobiome.
• Understanding the urobiome could impact genitourinary condition pathophysiology and therapeutics.

Purpose of the Study:

• Review existing pediatric urobiome literature.
• Focus on urinary tract infections, nephrolithiasis, and neurogenic bladder.
• Identify pediatric-specific considerations and future research directions.

Main Methods:

• Literature review of pediatric urobiome studies.
• Analysis of research concerning specific genitourinary conditions.
• Synthesis of findings to highlight knowledge gaps.

Main Results:

• The pediatric urobiome is under-researched across key genitourinary conditions.
• Specific considerations are needed for interpreting pediatric urobiome data.
• Potential for novel diagnostic and therapeutic targets exists.

Conclusions:

• Increased awareness of pediatric urobiome research is vital for clinicians and researchers.
• Further investigation is warranted to elucidate the role of the pediatric urobiome.
• This field holds promise for advancing pediatric urogenital health.