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Microarray Analysis of the Chemoprophylaxis Effect of Zinc Gluconate: Inspiring but Caution Required

Yuqing Wang1, Wei Liu2, Xinxin Xu3

  • 1School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Digestive Diseases and Sciences
|October 16, 2021
PubMed
Abstract

No abstract available in PubMed .

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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