Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
Same author

A zwitterionic-enabled one-pot electrochemical strategy for stable end-point detection of isothermal nucleic acid amplification.

Analytical methods : advancing methods and applications·2026
Same author

Self-adhesive, stretchable, and conductive hydrogel for self-powered flexible electronics.

Nanotechnology·2026
Same author

Dehydrogenase-like stacked MoS<sub>2</sub> nanozymes for cancer treatment through disrupting the tricarboxylic acid cycle.

Nanoscale·2026
Same author

Correction to "Visualization of Mechanical Force Regulation of Exosome Secretion Using High Time-Spatial Resolution Imaging".

Analytical chemistry·2026
Same author

A Tonic Signaling Code Predicts CAR-T Cell Efficacy in Diffuse Midline Glioma.

bioRxiv : the preprint server for biology·2025
Same journal

Zein-Ceria Hybrid Microparticles Enable Long-Term ROS-Scavenging Oxygenation for Osteogenic Microtissues Engineering.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Toward Practical Solid-State Lithium Batteries With High-Nickel Cathodes: An Interface-Centered Perspective.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

A Planarity-Hindrance Co-Balance Strategy to Develop Antiparallel H-Aggregates With Minimal Absorbance Blueshift for Type I Photodynamic Therapy.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Exceptional Rare-Earth Half-Heusler Thermoelectrics With Sublattice Softening.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Co-Assembled Hybrid Interlayer Engineering for Enhanced Upper Interface Stability in Inverted Perovskite Solar Cells.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Impact-Resistant Hydrogels Via Quaternary Ammonium-Regulated Networks.

Advanced materials (Deerfield Beach, Fla.)·2026
See all related articles

Related Experiment Video

Updated: Oct 16, 2025

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices
07:15

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

3.9K

Cell-Traction-Triggered On-Demand Electrical Stimulation for Neuron-Like Differentiation.

Zhirong Liu1,2, Mingjun Cai3, Xiaodi Zhang1

  • 1Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|October 16, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a smart piezoelectric scaffold that uses cell traction to generate electrical stimulation for tissue engineering. This novel approach supports stem cell differentiation by adapting to the dynamic cellular microenvironment.

Keywords:
dynamic microenvironmentfeedbackon-demand electrostimulationpiezoelectric scaffoldstem cell differentiation

More Related Videos

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.7K
Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments
11:15

Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

Published on: February 16, 2012

11.9K

Related Experiment Videos

Last Updated: Oct 16, 2025

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices
07:15

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

3.9K
Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.7K
Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments
11:15

Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

Published on: February 16, 2012

11.9K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cellular Mechanobiology

Background:

  • Cell-extracellular matrix interactions are fundamental in biology.
  • Understanding these electromechanical feedbacks is key for advanced electroactive tissue engineering scaffolds.
  • Current scaffolds lack adaptability to dynamic cellular environments.

Purpose of the Study:

  • To design a smart piezoelectric scaffold that mimics collagen stiffness for on-demand electrical stimulation.
  • To utilize cell traction as a feedback mechanism for regulating electrical stimulation.
  • To avoid negative impacts of premature electrical stimulation on cell behavior.

Main Methods:

  • Modulating dynamic mechanical forces within the cell microenvironment.
  • Developing a piezoelectric scaffold with tunable stiffness.
  • Implementing a cell-traction-mediated piezopotential generation system.

Main Results:

  • The scaffold generated a piezopotential for stem cell differentiation.
  • Cell traction served as a feedback loop, regulating stimulation.
  • The system adapted to the dynamic cellular microenvironment, providing on-demand stimulation.
  • Avoided adverse effects of early electrical stimulation on cell adhesion and spreading.

Conclusions:

  • This work presents the first scaffold that adapts to cellular microenvironments for on-demand electrical stimulation.
  • The cell-traction-mediated piezopotential approach offers a novel method for smart scaffold design.
  • This technology paves the way for advanced bioelectronic therapies and tissue regeneration.