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Updated: Oct 16, 2025

Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia
Lilly Velentza1, Farasat Zaman1, Lars Sävendahl2
1Division of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Abstract:
Glucocorticoids (GCs) are widely used in the treatment of childhood acute lymphoblastic leukemia (ALL), but their long-term use is also associated with bone-related morbidities. Among others, growth deficit, decreased bone mineral density (BMD) and increased fracture rate are well-documented and severely impact quality of life. Unfortunately, no efficient treatment for the management of bone health impairment in patients and survivors is currently available. The overall goal of this review is to discuss the existing data on how GCs impair bone health in pediatric ALL and attempts made to minimize these side effects.
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