Related Experiment Video

Updated: Oct 16, 2025

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies
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Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Published on: March 2, 2018

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Neutrophil microvesicles and their role in disease

Reece Dow1, Victoria Ridger1

  • 1Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.

The International Journal of Biochemistry & Cell Biology
|October 16, 2021
PubMed

Insights

Microvesicles, released by cells, carry molecules that can affect other cells and cause disease. Neutrophil microvesicles show potential as biomarkers for cardiovascular diseases like atherosclerosis.

Area of Science:

  • Cell biology
  • Biochemistry
  • Pathology

Background:

  • Microvesicles are released from the plasma membrane of nearly all human cells.
  • They are abundant in bodily fluids and carry cellular cargo (proteases, micro-RNAs, lipids).
  • Surface molecules identify their parental cell, aiding investigation into disease pathogenesis.

Purpose of the Study:

  • To review microvesicle formation and function.
  • To focus on neutrophil microvesicles in cardiovascular disease.
  • To explore their potential role and underlying mechanisms in disease.

Main Methods:

  • Review of existing literature on microvesicle biogenesis and function.
  • Analysis of studies investigating neutrophil microvesicles.
  • Discussion of potential mechanisms in cardiovascular disease pathogenesis.

Main Results:

  • Microvesicles can alter target cell function through cargo delivery.
  • Neutrophil microvesicles have been implicated in atherosclerosis.
  • Microvesicle profiles may serve as future diagnostic biomarkers.

Conclusions:

  • Microvesicles play a significant role in intercellular communication and disease.
  • Neutrophil microvesicles are a key area of research for cardiovascular disease.
  • Further investigation is needed to elucidate their precise role and therapeutic potential.

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