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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
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Janus kinase 2 (JAK2) methylation and obesity: A Mendelian randomization study
Runqi Tu1, Xiaotian Liu1, Xiaokang Dong1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|October 17, 2021
Summary
This study investigated the link between Janus kinase 2 (JAK2) methylation and obesity. Mendelian randomization analysis revealed a causal relationship between JAK2 methylation levels and obesity risk.
Area of Science:
- Epigenetics and Metabolism
- Human Genetics and Disease Etiology
Background:
- Janus kinase 2 (JAK2) is implicated in energy metabolism.
- The precise relationship between JAK2 methylation and obesity is not fully understood.
Purpose of the Study:
- To explore the potential causal relationship between JAK2 methylation levels and obesity.
- Utilizing Mendelian randomization analysis with single nucleotide polymorphism (SNP) instrumental variables.
Main Methods:
- Analysis of 1021 participants (511 cases, 510 controls) from the Henan Rural Cohort study.
- Genotyping of SNPs and measurement of DNA methylation levels.
- Logistic regression and Mendelian randomization analyses to assess associations and causality.
Main Results:
- Logistic regression identified specific CpG sites in JAK2 promoter and exon regions associated with obesity risk.
- Mendelian randomization analysis, using 5 SNPs as instrumental variables, demonstrated a causal association between JAK2 methylation and obesity.
Conclusions:
- The methylation degree of JAK2 exhibits a complex, region-dependent relationship with obesity.
- A causal link is established between JAK2 methylation levels and obesity.
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