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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Determination Of Ca 19-9 Antigen In Serum And Pancreatic Juice For Differential Diagnosis Of Pancreatic Adenocarcinoma From Chronic Pancreatitis.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Determination Of Ca 19-9 Antigen In Serum And Pancreatic Juice For Differential Diagnosis Of Pancreatic Adenocarcinoma From Chronic Pancreatitis.

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Determination of CA 19-9 antigen in serum and pancreatic juice for differential diagnosis of pancreatic adenocarcinoma from chronic pancreatitis.

A Malesci, M A Tommasini, C Bonato

    Gastroenterology
    |January 1, 1987

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Serum CA 19-9 levels are highly effective in diagnosing pancreatic cancer versus chronic pancreatitis. However, moderately elevated levels may not be conclusive for malignancy, suggesting further testing is needed.

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    Area of Science:

    • Oncology
    • Gastroenterology
    • Biochemistry

    Background:

    • Distinguishing pancreatic cancer from chronic pancreatitis is clinically significant.
    • Serum CA 19-9 is a known tumor marker, but its utility in differentiating these conditions requires further investigation.

    Purpose of the Study:

    • To evaluate the diagnostic accuracy of serum CA 19-9 levels for pancreatic cancer versus chronic pancreatitis.
    • To assess the role of CA 19-9 in pancreatic juice for early detection of pancreatic adenocarcinoma.

    Main Methods:

    • Serum CA 19-9 levels were measured in patients with pancreatic cancer and chronic pancreatitis.
    • Pure pancreatic juice was obtained endoscopically to measure CA 19-9 concentrations and ratios.
    • Statistical analysis was performed to compare marker levels between groups.

    Main Results:

    • Serum CA 19-9 was elevated in 90% of pancreatic cancer patients versus 10% of chronic pancreatitis patients.
    • Falsely normal serum CA 19-9 levels were associated with poorly differentiated carcinomas.
    • CA 19-9 concentrations and CA 19-9 to protein ratios in pancreatic juice were significantly higher in cancer patients.

    Conclusions:

    • Serum CA 19-9 is a sensitive and specific marker for differentiating pancreatic cancer from chronic pancreatitis.
    • Moderately elevated serum CA 19-9 levels (<120 U/ml) may not be conclusive for malignancy in localized disease.
    • CA 19-9 to total protein ratio in pancreatic juice shows promise as an adjunctive marker for early-stage pancreatic adenocarcinoma.