Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

66.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
66.5K
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

2.3K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
2.3K
Menses Phase01:18

Menses Phase

536
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
536
Histology of the Uterus01:19

Histology of the Uterus

2.2K
The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
2.2K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

821
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
821
Secretory Phase01:19

Secretory Phase

1.4K
The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply: Evaluation of methodological and analytical approaches in assessing intra-individual serum progesterone variability on frozen embryo transfer day across hormone replacement therapy cycles.

Human reproduction (Oxford, England)·2025
Same author

Perioperative iron deficiency and anaemia in scheduled gynaecological surgery: An update based on findings from the PERIOPES and CARENFER studies: Iron deficiency in gynaecological surgery.

Journal of gynecology obstetrics and human reproduction·2025
Same author

Reduced live birth rates following ART in adenomyosis patients: a matched control study.

Human reproduction (Oxford, England)·2025
Same author

Reply: Sticking to the facts instead of speculating: evidence against intensive luteal phase support in endometriosis patients undergoing HRT-FET cycles.

Human reproduction (Oxford, England)·2024
Same author

Distribution of endometriosis phenotypes according to patients' age in adult women with surgical evaluation.

Human reproduction (Oxford, England)·2024
Same author

Progesterone levels do not differ between patients with or without endometriosis/adenomyosis both in those who conceive after hormone replacement therapy-frozen embryo transfer cycles and those who do not.

Human reproduction (Oxford, England)·2024

Related Experiment Video

Updated: Oct 16, 2025

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

16.1K

[Adenomyosis pathophysiology: An unresolved enigma].

M Bourdon1, P Santulli1, L Marcellin1

  • 1Université de Paris, faculté de santé, faculté de médecine Paris Centre, Paris, France; Assistance publique-Hôpitaux de Paris (AP-HP), hôpital universitaire Paris Centre (HUPC), centre hospitalier universitaire (CHU) Cochin, département de gynécologie obstétrique II et médecine de la reproduction, Paris, France; Département 3I « infection, immunité et inflammation », Cochin Institute, INSERM U1016, Paris, France.

Gynecologie, Obstetrique, Fertilite & Senologie
|October 17, 2021
PubMed
Summary

Adenomyosis, a uterine disease where endometrial tissue invades the uterine muscle, has complex causes. This review updates theories on its pathophysiology, linking it to symptoms and treatments.

Keywords:
AdenomyosisAdénomyoseEndometriumEndomètreMyometriumMyomètrePhysiopathologiePhysiopathologySymptomsSymptômes

More Related Videos

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.5K
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:07

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

1.0K

Related Experiment Videos

Last Updated: Oct 16, 2025

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

16.1K
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.5K
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:07

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

1.0K

Area of Science:

  • Gynecology
  • Reproductive Medicine
  • Pathophysiology

Background:

  • Adenomyosis is a chronic, benign uterine condition.
  • Characterized by endometrial glands and stroma within the myometrium.
  • Presents heterogeneously with varied clinical manifestations.

Purpose of the Study:

  • To provide an update on adenomyosis pathophysiology.
  • To review theories on myometrial invasion by endometrial cells.
  • To explore the link between pathophysiology, symptoms, and treatments.

Main Methods:

  • Literature review of adenomyosis pathophysiology.
  • Analysis of proposed theories on lesion development.
  • Examination of hormonal, immune, and genetic factors.

Main Results:

  • Adenomyosis pathophysiology remains complex with multiple proposed theories.
  • Potential origins include Mullerian rests or stem cells.
  • Hormonal, immune, and genetic factors may initiate lesions.

Conclusions:

  • Understanding adenomyosis pathophysiology is crucial for managing symptoms.
  • Further research into inducing mechanisms is needed.
  • Connecting pathophysiology to clinical presentation guides treatment strategies.