Related Experiment Video
Updated: Oct 16, 2025
08:45
Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
Published on: April 18, 2025
526
Is Isolated Diastolic Hypertension an Important Phenotype?
Cesar A Romero1, Aldo H Tabares2, Marcelo Orias3
1Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Current Cardiology Reports
|October 17, 2021
Summary
Isolated diastolic hypertension (IDH) is common. A new category, predominantly diastolic hypertension (PDH), is proposed to include IDH and narrow pulse pressure systolic-diastolic hypertension, aiding future research and therapy.
Area of Science:
- Cardiology
- Hypertension Research
- Clinical Medicine
Background:
- Isolated diastolic hypertension (IDH) is a frequent phenotype.
- Recent guideline changes have increased IDH prevalence.
- The long-term cardiovascular risk and treatment of IDH remain debated.
Purpose of the Study:
- To review the pathophysiology, risk stratification, and therapeutic decisions for IDH.
- To propose a broader category for diastolic hypertension.
- To highlight the need for standardized definitions in IDH research.
Main Methods:
- Review of existing literature on IDH.
- Analysis of physiological and epidemiological characteristics.
- Comparison of IDH with systolic-diastolic hypertension (SDH) subgroups.
Main Results:
- Lowered blood pressure cutoffs increase IDH prevalence.
- IDH shares characteristics with a subgroup of SDH.
- A proposed category of predominantly diastolic hypertension (PDH) includes IDH and narrow pulse pressure SDH.
- PDH is linked to long-term cardiovascular risk, particularly in younger individuals.
Conclusions:
- IDH and narrow pulse pressure SDH may be grouped as PDH (pulse pressure ≤ 45 mmHg).
- This broader classification may improve understanding of cardiovascular risk.
- Standardization of IDH definitions is crucial for future research into genetics, pathophysiology, and treatment.
Keywords:
Hypertension in young patientsHypertension prognosisIsolated diastolic hypertensionNarrow pulse pressurePredominantly diastolic hypertensionMore Related Videos
09:40Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Published on: April 11, 2016
21.2K
11:04Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
Published on: September 1, 2014
11.3K
Related Concept Videos
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
104
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
104
01:28Hypertension I: Introduction
172
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
172
01:29Hypertension II: Pathophysiology
173
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
173
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
94
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
94
01:17Measurement of Blood Pressure
1.8K
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
1.8K
01:30Alterations in Blood Pressure
1.5K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.5K