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Asthma Detection Research Based on Voice Signal Processing and Machine Learning
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Association between YKL-40 and asthma: a systematic meta-analysis.

Yihan Jin1, Jie Song1, Fang Xu2

  • 1Department of Respiratory Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.

Sleep & Breathing = Schlaf & Atmung
|October 17, 2021
PubMed
Summary

Serum YKL-40 levels are elevated in asthma patients and correlate with disease severity and exacerbations. This protein may aid in asthma diagnosis and differentiating it from COPD and ACO.

Keywords:
AsthmaClinical trialsMeta-analysisSystematic reviewYKL-40

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Area of Science:

  • Biochemistry
  • Pulmonology
  • Clinical Diagnostics

Background:

  • Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is implicated in various inflammatory conditions.
  • Previous research suggests a link between YKL-40 and asthma, but its precise role requires further clarification.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the utility of serum YKL-40 in asthma diagnosis.
  • To assess YKL-40's role in grading asthma severity and determining disease state.
  • To investigate YKL-40's effectiveness in the differential diagnosis of asthma from COPD and ACO.

Main Methods:

  • A systematic meta-analysis was performed.
  • Searches were conducted across PubMed, Ovid, and Cochrane databases.
  • Data from 17 articles encompassing 5696 subjects were analyzed.

Main Results:

  • Serum YKL-40 levels were significantly higher in asthma patients compared to healthy individuals, irrespective of age or location.
  • YKL-40 levels increased with asthma severity and during acute exacerbations.
  • Significant differences in YKL-40 levels were observed between asthma, COPD, and asthma-COPD overlap syndrome (ACO).

Conclusions:

  • YKL-40 shows potential as a serological marker for asthma diagnosis.
  • Serum YKL-40 can aid in assessing asthma severity and disease status.
  • YKL-40 may be valuable for differentiating asthma from COPD and ACO.