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Differences in Functional Brain Networks Between Subjective Cognitive Decline with and without Worry Groups: A Graph
Yi Liu1, Zhuoyuan Li2, Xueyan Jiang3,4
1Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Journal of Alzheimer'S Disease : JAD
|October 18, 2021
Summary
Worry in individuals with subjective cognitive decline (SCD) alters functional brain networks, increasing connectivity and risk. These changes in brain networks may predict future cognitive decline.
Area of Science:
- Neuroscience
- Cognitive Science
- Medical Imaging
Background:
- Subjective cognitive decline (SCD) with worry is linked to increased cognitive decline risk.
- The impact of worry on SCD functional brain networks remains unclear.
Purpose of the Study:
- To investigate differences in functional brain networks between SCD individuals with and without worry.
- To explore how worry influences brain network characteristics in SCD.
Main Methods:
- Utilized resting-state functional magnetic resonance imaging (rs-fMRI) on 228 participants (NC, SCD with worry, SCD without worry).
- Applied graph theory to analyze whole-brain and default mode network (DMN) functional connectivity.
- Calculated network parameters: clustering coefficient, shortest path length, local and global efficiency.
Main Results:
- SCD with worry exhibited increased functional connectivity and shortest path length compared to SCD without worry.
- The SCD with worry group showed decreased clustering coefficient, global efficiency, and local efficiency.
- These network alterations were observed in both the whole brain and the DMN.
Conclusions:
- Significant differences in functional brain networks exist between SCD individuals with and without worry.
- Worry may induce functional brain network alterations in SCD, potentially increasing cognitive decline risk.