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Central Nervous System-related Graft-versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Yuta Kaito1, Shunsuke Yui1, Kazuki Inai1

  • 1Department of Hematology, Nippon Medical School, Japan.

Internal Medicine (Tokyo, Japan)
|October 18, 2021
PubMed

Allogeneic hemopoietic stem cell transplantation (allo-HSCT) is the only curative therapy for refractory hematological malignancies. However, there are many treatment-related complications, including organ disorders, graft-versus-host disease (GVHD), and infectious diseases. Furthermore, there are many unclear points regarding central nervous system (CNS) complications, and the prognosis in patients with CNS complications is extremely poor. We herein report a 49-year-old woman who developed CNS-GVHD after a second transplantation for therapy-related myelodysplastic syndrome. CNS-GVHD in this case was refractory to all treatments, including steroids, and progressed. We also present a review of the literature about the symptoms, diagnosis, and treatment of CNS-GVHD.

Keywords:
allogeneic hematopoietic stem cell transplantationcentral nervous system complicationscentral nervous system graft-versus-host diseasegraft-versus-host disease

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