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Putting Anion-π Interactions at Work for Catalysis.

Na Luo1,2, Yu-Fei Ao1,2, De-Xian Wang1,2

  • 1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|October 18, 2021
PubMed
Summary

Anion-π catalysis utilizes electron-deficient π surfaces to stabilize anionic intermediates and transition states. This review highlights key progress in anion-π interactions for catalysis, from ground-state to transition-state stabilization.

Keywords:
anion bindinganion-π catalysisanion-π interactionssupramolecular catalysisπ-acidic surface

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Area of Science:

  • Supramolecular Chemistry
  • Catalysis
  • Physical Organic Chemistry

Background:

  • Anion-π interactions, recognized for two decades, are crucial in chemical processes.
  • Theoretical and experimental studies established anion-π binding and recognition principles.
  • These principles form the foundation for exploring anion-π interactions in catalysis.

Purpose of the Study:

  • To review the emergence and development of anion-π catalysis.
  • To emphasize the general concept and key advancements in this field.
  • To organize content based on the role of anion-π interactions in catalytic processes.

Main Methods:

  • Review of theoretical and experimental studies on anion-π interactions.
  • Categorization of anion-π roles in catalysis: ground-state and transition-state stabilization.
  • Analysis of stabilization mechanisms: single π-face and cooperative π-face activation.

Main Results:

  • Anion-π catalysis employs π-acidic surfaces for stabilizing anionic species.
  • Key progress includes stabilization from ground-state to transition-state.
  • Mechanisms range from single π-face interactions to cooperative π-face activation.

Conclusions:

  • Anion-π interactions are a significant driving force in catalysis.
  • The concept of anion-π catalysis offers novel strategies for chemical transformations.
  • Future developments are anticipated in this rapidly advancing field.