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Epigenetics and DOHaD: how translation to predictive testing will require a better public understanding
Fiona Lynch1,2, Sharon Lewis1,2, Ivan Macciocca1,3
1Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Journal of Developmental Origins of Health and Disease
|October 18, 2021
Summary
Epigenetics and Developmental Origins of Health and Disease (DOHaD) interventions may reduce non-communicable disease (NCD) risk. Public understanding of these concepts is crucial for intervention acceptance and future healthcare integration.
Area of Science:
- Environmental epigenetics
- Non-communicable disease (NCD) etiology
- Developmental Origins of Health and Disease (DOHaD) theory
Background:
- Epigenetics mediates gene-environment interactions influencing NCD risk.
- DOHaD theory suggests early life interventions can modify epigenetic profiles and NCD risk.
- Public perception of epigenetics and DOHaD impacts intervention willingness.
Purpose of the Study:
- To review epigenetics, DOHaD, and NCD links.
- To explore issues of epigenetic risk prediction and predictive testing in children.
- To assess current understanding of public opinion on epigenetics, DOHaD, and NCDs.
Main Methods:
- Literature review of epigenetics, DOHaD, and NCDs.
- Analysis of public awareness and opinion regarding epigenetic concepts.
- Exploration of ethical considerations in epigenetic testing.
Main Results:
- Epigenetic modifications are key in NCD development.
- Early life interventions hold potential for NCD risk reduction.
- Public knowledge and attitudes towards epigenetics require further investigation.
Conclusions:
- Understanding public perception is vital for implementing epigenetic interventions.
- Future research must address public awareness of epigenetics for healthcare integration.
- Health professionals need information on public understanding for introducing epigenetic testing.
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