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The risk of endothelial and erectile dysfunctions in Behçet's disease: a comparative analysis of mucocutaneous and
Yasemin Erdem1, Selcuk Erdem2, Mehmet Barburoglu3
1Department of Dermatology, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
Insights
Men with Behçet's disease (BD) have similar rates of endothelial and erectile dysfunction, regardless of whether it affects only mucocutaneous tissues or multiple systems. This suggests a consistent risk for these vascular complications in all BD patients.
Area of Science:
- Vascular Medicine
- Rheumatology
- Urology
Background:
- Behçet's disease (BD) is a chronic inflammatory condition with variable systemic involvement.
- BD can manifest with mucocutaneous symptoms or affect multiple organ systems.
Purpose of the Study:
- To compare endothelial dysfunction (EnD) and erectile dysfunction (ED) between patients with mucocutaneous BD (MBD) and systemic BD (SBD).
- To investigate the association between disease phenotype and vascular complications in Behçet's disease.
Main Methods:
- Thirty-eight male BD patients were divided into MBD (n=20) and SBD (n=18) groups.
- Endothelial dysfunction assessed via coronary flow reserve (CFR < 2). Erectile dysfunction assessed using the International Index of Erectile Function (IIEF-EF) and Penile Doppler Ultrasonography (PDU).
Main Results:
- No significant differences in ED prevalence (IIEF-EF and PDU) or EnD (CFR < 2) between MBD and SBD groups.
- Systemic BD patients had a longer disease duration and higher use of immunosuppressants.
- Overall prevalence of EnD was 52.6% and ED was 45% (IIEF-EF) or 10% (PDU).
Conclusions:
- Endothelial and erectile dysfunctions occur with similar frequency in both mucocutaneous and systemic Behçet's disease.
- The risk of vascular complications like EnD and ED should be considered in all male patients diagnosed with Behçet's disease.
Introduction:
Behçet's disease (BD) is a chronic inflammatory disease which can be limited to only mucocutaneous tissues or can affect different systems of the body.
Aim:
To investigate the association of endothelial and erectile dysfunctions with BD, on the basis of comparative analysis between mucocutaneous and systemic BD.
Material And Methods:
Thirty-eight men diagnosed with BD were included in the present study. The patients were stratified into two groups as mucocutaneous BD (n = 20, MBD group), and systemic BD (n = 18, SBD group). Erectile dysfunction (ED) was assessed using the Erectile Function domain of the International Index of Erectile Function (IIEF-EF) questionnaire. The coronary flow reserve (CFR) assessment was done for analysing endothelial dysfunction (EnD), and CFR < 2 was defined as EnD. Penile Doppler ultrasonography (PDU) was performed for ED. The demographic and clinical parameters, IIEF-EF score ED classification, CFR and PDU test findings were compared between two groups.
Results:
The median age was 34 (22-52) years in the overall population, and there was no difference between two groups (p = 0.558). Time from diagnosis was significantly longer (24 vs. 102 months, p = 0.021) and the use of immunosuppressive therapies was higher (0 vs. 70.6%, p < 0.001) in the SBD group. In overall, median CFR was 1.92 (1.1-5.96), and there was no difference between two groups (1.88 vs. 1.97, p = 0.812). The percentage of patients with CFR < 2 was similar in two groups (52.6% vs. 52.9%, p = 0.985). The ED status according to IIEF-EF was similar in two groups (45% vs. 27.8%, p = 0.538) as well as according to PDU analyses (10% vs. 16.7%, p = 0.544).
Conclusions:
The increased risk of endothelial, and erectile dysfunctions should be considered in men who were diagnosed with mucocutaneous and systemic BD.
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